Rome and Parthia fought a series on wars and skirmishes for control of the Middle East. The Parthian Empire fell around 224 A.D. It wasn't Rome, but internal and external factors broke the empire apart. Parthia's decline and fall helped open the door for eastern tribes to later invade the Roman Empire. The Sassanid Empire formed in its wake and existed until the Muslim conquest.
The following is from a documentary:
http://www.youtube.com/watch?v=IJ_1bshHnD8
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